Cytochrome P450 3A4/3A5 genotyping-994

Test info

  
Cytochrome P450 3A4/3A5 genotyping
  
994
  
LAB994
  
MSO
  
CYP3A4
CYP3A5
  

This test provides genotypes for CYP3A4 and CYP3A5 and determines estimated metabolic activity. CYP3A4 and CYP3A5 cytochrome P450 enzymes are involved in the hepatic metabolism of up to 50% of all clinically used drugs. There is wide variation in enzyme activity, particularly for CYP3A4 (10-100 fold), due to both genetic and nongenetic factors. The cause of much of the variation is not yet understood.

Specimen

  
EDTA whole blood
  
  
7 mL
  
3.0 mL
  

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times to prevent clotting

  

Lavender (EDTA), 10mL

  
ACD whole blood
  

Yellow ACD (A or B)

 

  

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times to prevent clotting

  

Yellow ACD (A or B)

  

Molecular Medicare billing request

Hospital clients submitting a reqeust for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request along with the sample

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

  
  • Frozen specimen
  •  Hemolysis
  • Quantity not sufficient for analysis (QNS)
  • Improper container

Performance

  
LabCorp Burlington (504155): R-NX
  
Tu
  
7 - 10 days
  

Multiplex polymerase chain reaction (PCR) and primer extension

Clinical and Interpretive info

  

Normal

Billing

  
81230
81231
  
Yes
  
  
Result:
3A4 Genotype: 81139-8
3A5 Genotype: 81140-6

Tracking

  
07/31/2019
  
02/03/2021
  
06/03/2020