This assay is used to screen Merkel Cell Carcinoma (MCC) patients for current or prior infection with the Merkel cell polyomavirus.
Patients who lack these antibodies should not be monitored with additional AMERK testing because they do not make antibodies to the viral oncoprotein and should be monitored by other means. VP1 capsid antibodies are not an indicator of disease activity.
Lipemia may increase results 15 - 20%
Immediatley following collection, mix sample by gently inverting 5 times
Gold serum separator (SST) tube
False bottom plasma/serum transport vial/tube (AHL)
Refrigerated (preferred) – 7 days
Ambient – 7 days
Frozen – Long term
Laboratory developed Luminex paramagnetic bead, multiplex assay
SmT oncoprotein antibodies are present in the blood of 50% of patients when they have clinically detectable Merkel Cell Carcinoma (MCC). In patients who make oncoprotein antibodies, titers are expected to decrease significantly within 3 months of successful treatment of MCC. Changes in oncoprotein titers of less than 25% may not be biologically significant. A significant rise in titer or stabilization above 2000 STU may be associated with persistent or recurrent MCC.