Propeptide Type 1 Collagen-13400

Test info

  
Propeptide Type 1 Collagen
  
13400
  
LAB13400
  
PINP
  
Intact N-terminal propeptide of type 1 procollagen
P1NP
  

This test is used for measurement of Intact N-Terminal Propeptide of Type 1 Procollagen (PINP) levels in serum.

  

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or  coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Specimen

  
Serum
  
  
0.5 mL
  
0.4 mL
(Note: This volume does not allow for repeat testing.)
  

Immediately following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within 45 minutes of sample collection
  

Gold serum separator (SST) tube

  
  
  1. Allow sample to clot
  2. Spin within 45 minutes of collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days 

Freeze/thaw cycle: Stable x 3

  

Non-serum sample received

Performance

  
LabCorp Burlington (140850): R-LC
  
Tu, Th
  
3-5 days
  

Immunochemiluminometric assay (ICMA)

Clinical and Interpretive info

  

Premenopausal females: 13.9-89.1 ng/mL

Postmenopausal females: 10.4-97.8 ng/mL

Males ≤ 45 years of age: 21.8-96.0 ng/mL

Males >45 years of age: 18.3-86.1 ng/mL

  
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. When evaluating subsequent samples, collect the samples at the same time of the day, as there is a diurnal variation of P1NP with the values being higher at night. The measurement of P1NP has limited specificity as it is reflective of the rate of bone turnover in general. Type I collagen is synthesized by fibroblasts and therefore can be found in loose connective tissues together with other collagen types. However, since bone is the major collagenous organ and also metabolically active throughout life, the majority of the circulating P1NP is of osteoblast origin. PINP is metabolized in the liver. Severe liver disease may affect clearance from the circulation and give rise to elevated serum P1NP levels. As with most assays utilizing secondary antibodies, samples containing antibodies (such as heterophilic antibodies) that react with rabbit/goat IgG may cause erroneous results.

Billing

  
82523
  
Yes
  
  
Result 47255-5

Tracking

  
04/09/2019
  
08/22/2023
  
08/22/2023