Everolimus-13477

Test info

  
Everolimus
  
13477
  
LAB13477
  
EVER
  
Afinitor
Certican
Everolimus, whole blood
Zortress
  

Everolimus is a proliferation signal inhibitor that prevents allograft rejection. It exerts its immunosuppressive effect by inhibiting the proliferation, and thus clonal expansion, of antigen-activated T-cells, which is driven by T-cell-specific interleukins. Everolimus inhibits an intracellular signaling pathway that is triggered up binding of these T-cell growth factors to their respective receptors, and which normally leads to cell proliferation. The blockage of this signal by everolimus leads to an arrest of the cells at the G1 stage of cell cycle.

Specimen

  

Trough levels are most reproducible

  
EDTA whole blood
  
  
2.0mL
  
0.5mL
  

Immediatley following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

  

Lavender (EDTA), 4mL

  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

Performance

  
LabCorp Burlington (700003): R-LC
  
Daily
  
2 - 4 days
  

Liquid chromatography/tandem mass spectometry (LC-MS/MS)

Clinical and Interpretive info

  

3.0 - 8.0 ng/mL

Billing

  
80169

Tracking

  
03/29/2019
  
06/13/2023
  
05/30/2023