Tau by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test info

Tau by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Tau is used to identify neurofibrillary tangles in Alzheimer's disease1-2 and in a family of neurodegenerative disorders collectively referred to as Tauopathies3
  • Alzheimer's disease is usually associated with a stereotyped progression of neurofibrillary pathology, with NFTs involving trans-entorhinal structures, limbic system, and finally isocortex1-2
  • Small numbers of NFTs are seen in cognitively normal elderly4



Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair


AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination

Clinical and Interpretive info


If requested, an interpretive report will be provided



  • Tau protein is a microtubule associated protein present in normal brain and neuronal diseases
  • Tau is present in the axons of the central and peripheral nervous system
  • Accumulations of Tau are present in neurodegenerative diseases in the form of cytoplasmic neurofibrillary tangles (NFTs)

Staining pattern

  • Cytoplasmic


  1. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 1991;82:239-59.
  2. Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur Neurol 1993;33:403-8.
  3. Dickson DW, Neuro-degeneration: The Molecular Pathology of Dementia and Movement Disorders, ISN Neuropath Press, Basel 2003, 414 pp.
  4. Knopman DS, et al. Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol 2003;62(11):1087-95.




88342 - 1st stain
88341 - each additional stain