Mannose binding lectin-994

Test info

  
Mannose binding lectin
  
994
  
LAB994
  
MSO
  
MBL
  

The determination of MBL concentrations in serum may be useful for the elucidation of suspected immune defects and as a prognostic indicator alerting to the need for heightened therapeutic or prophylactic measures in immunosuppressed patients, including patients receiving cancer chemotherapy and patients with cystic fibrosis, SLE, or rheumatoid arthritis.

Specimen

  
Serum
  
  
0.5 mL
  
0.1 mL
Submission of the minimum volume does not allow for repeat testing
  

Immediately following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within two (2) hours of sample collection
  

Gold serum separator (SST) tube

 

  
  
  1. Allow sample to clot
  2. Spin within two (2) hours of sample collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
  
  

Ambient (preferred) - 14 days 

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

  
  • Non-serum sample
  • Hemolysis
  • Lipemia

Performance

  
LabCorp (004900): R-NX
  
We
  
8 days
  

Enzyme-linked immunosorbent assay (ELISA) using microwells coated with the unique monoclonal antibody to capture MBL via an epitope near its carbohydrate-binding site. Bound MBL is detected with the same antibody that has been labeled with biotin.

Clinical and Interpretive info

  

Low: 0 - 50 ng/mL

Intermediate: 51 - 500 ng/mL

Normal: >500 ng/mL

 

  

Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis.

Billing

  
83520

Tracking

  
01/10/2020
  
12/20/2023
  
12/20/2023