CD68 by IHC

Alphabetical Test listing

CD68 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
CD68 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
KP1
  
  • All IHC stains will include a positive control tissue
  
  • KP1 reacts with cells of monocyte/macrophage or myelomonocytic lineage (this includes epithelial histiocytes, multinucleated histiocytes, osteoclasts, giant cells in giant cell tumors of bone, Gaucher's cells, sea blue histiocytes)
  • KP1 will also react with neutrophils, mast cells and basophils; and will stain myeloid leukemias (useful in the workup of a chloroma)
  • KP1 can stain a wide variety of non-Hodgkin's lymphomas of B-cell phenotype (most frequently KP1 positive NHL's are small lymphocytic and diffuse, small cleaved NHL)
  • KP1 stains granular cell tumors, and Schwann cells in benign peripheral nerve sheath tumors
  • KP1 is not highly specific; KP1 also may react with hepatocytes, kidney tubules and glomeruli, pancreatic acini and islets, skin epithelium, sweat glands, connective tissue, and endothelial cells
  • KP1 reactivity has also been reported in MFH, renal cell carcinoma, malignant melanoma, meningioma, glioblastoma, infiltrating duct carcinoma of the breast
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • CD68/KP1 is an antibody that recognizes an intracellular glycoprotein associated with lysosomes, phagosomes, and primary granules of neutrophils. It is a very useful marker for identifying macrophages/histiocytes

Staining pattern

  • Granular cytoplasmic based staining

References

  1. Weiss, et. al.: CD68; A Review; Appl. Immunohistochemistry 2(1):2-8, 1994.
  2. Horny, et. al.: Assessment of the Value of Immunohistochemistry in the Subtyping of Acute Leukemia on Routinely Processed Bone Marrow Biopsy.
  
88342 - 1st stain
88341 - each additional stain
  
06/16/2017
  
10/18/2018
  
10/02/2020