Warfarin, serum or plasma

Alphabetical Test listing

Warfarin, serum or plasma-994

  
Warfarin, serum or plasma
  
994
  
LAB994
  
MSO
  
Coumadin
Jantoven
Sodium Warfarin
  

Warfarin is used for chronic oral anticoagulation in a variety of clinical settings. Management of warfarin therapy is usually by following the prothrombin time, rather than by measuring serum drug concentrations. Warfarin is subject to a bewildering number and variety of drug interactions, producing increased or decreased clinical effect of itself or other drugs. Many of these effects are due to changes in protein binding or hepatic metabolism. Reductions in dosage may be indicated for aging subjects treated for venous thromboembolic or coronary arterial disease, but not in those with peripheral vascular disease, deep vein thrombosis, or valvular heart disease.

The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

  
Serum
  
  
2.0 mL
  
0.6 mL
  
  1. Allow sample to clot
  2. Spin
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum, within two (2) hours of sample collection
  
EDTA plasma
Heparin plasma
  

Lavender (EDTA), 4mL

Dk green heparin (Li or Na), no gel

 

  

Immediately after collection, mix tube thoroughly by gentle inversion, 8 - 10 times, to prevent clotting

  
  1. Spin
  2. Transfer plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as EDTA or Heparin plasma, within two (2) hours of sample collection
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

  
  • Gel-barrier tube
  
LabCorp Burlington (071423): R-NX
  
Mo - Fr
  
2 - 4 days
  

Liquid chromatography tandem mass spectrometry (LC-MS/MS)

  

1.0-10.0 μg/mL

  
80375
  
Result 4098-0
  
05/22/2019
  
05/22/2019