ATM/TP53 by FISH

Alphabetical Test listing

ATM/TP53 by FISH-4280G (bone marrow) or 4280H (blood)

  
ATM/TP53 by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
ATM/TP53
  
CLL
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
ATM
TP53
TP53 Deletion
11q-
11q22
17p13.1
  

Deletion of 11q22 (ATM) and 17p13.1 (TP53) are recurring abnormalities of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). According to current NCCN CLL guidelines, deletions of 11q22 and 17p13.1 are classified as an unfavorable cytogenetic risk factor.

This test can be ordered individually or as part of a CLL Full Panel, CLL Prognostic Panel, or CLL Progressive Panel. See the individual panel tests for more details.

  
Bone Marrow aspirate
  

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

  1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
  2. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container. 

  

Submit entire specimen unspun.

  

Sterile vial/tube

  

or

Dk green Sodium heparin (Na hep), no gel

  
Bone Marrow Core
Whole blood
Touch Prep Slides
  

Bone Marrow Core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  
Bone Marrow core: 10 mm
Whole blood: 5 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

  

Submit entire specimen unspun

  
  

AHL Cytogenetics Oncology Request

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair
  
AHL - Cytogenetics: X
  
Mo - Fr
  
5 business days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

 

  
88271 x 2
88275
88291
  
Yes
  
  
03/18/2021
  
09/28/2022
  
09/28/2022