Deletion of 11q22 (ATM) and 17p13.1 (TP53) are recurring abnormalities of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL).
This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (see the individual panel tests for more details).
Dk green Sodium heparin (Na hep), no gel
Bone marrow
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
EDTA whole blood:
Lavender (EDTA), 4mL
Bone marrow:
Sterile vial/tube
Dk green Sodium heparin (Na hep), no gel
Ambient
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.
A deletion of either 11q22 (ATM) or 17p13.1 (TP53) is classified as an unfavorable cytogenetics prognostic indicator in CLL/SLL according to NCCN.