Cytokeratin 18 by IHC

Alphabetical Test listing

Cytokeratin 18 by IHC-12376 - Technical only, 12379 - Technical & interpretation

Cytokeratin 18 by IHC
12376 - Technical only, 12379 - Technical & interpretation

All IHC stains will include a positive control tissue

  • CK 18 is one of the most commonly found intermediate filaments in epithelial cells
  • This cytokeratin is expressed in single layer ductal/glandular epithelial cells, throughout the body (is not present in squamous epithelium)
  • This marker is often used to identify endometrial cancers
  • CK 18 frequently is present with CK8; mutations of these genes associated with these cytokeratins increase susceptibility to liver disease (cryptogenic cirrhosis)

Submit a formalin-fixed, paraffin-embedded tissue


Formalin-fixed, paraffin-embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Antibody recognizes human cytokeratin 18 intermediate filament protein, 45 KDa

Staining pattern

  • Cytoplasmic based

88342 - 1st stain
88341 - each additional stain