MYC by FISH [peripheral blood or bone marrow]]

Alphabetical Test listing

MYC by FISH [peripheral blood or bone marrow]]-4280H (blood) or 4280G (bone marrow)

  
MYC by FISH [peripheral blood or bone marrow]]
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
6Q21/MYC
  
CLL
CLL Full Panel
Chronic Lymphocytic Leukemia
MYC
SLL
Small Lymphocytic lymphoma
8q24
8q24 rearrangement
  

Rearrangement of MYC is a common abnormality in Acute B-Cell Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL) and an indication of a histologic (Richter’s) transformation.

This test can be ordered individually or as part of a CLL full panel (see the individual panel test for more details).

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2 mL
  
  • Only one specimen tube is required to perform all ordered cytogenetics testing.
  • The more testing ordered, the closer to the optimal volume requirements is preferred.
  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood (not recommended):

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

Whole blood:

Lavender (EDTA), 4mL

  
  • AHL Cytogenetics oncology requisition
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container
  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

Although not listed in the NCCN cytogenetics prognostic table, a MYC rearrangement may activate transcription and be an indication of a histologic (Richter’s) transformation to a more aggressive lymphoma.

  
88271 x 2
88275
  
Yes
  
03/18/2021
  
04/06/2021