Annexin A1 by IHC

Alphabetical Test listing

Annexin A1 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Annexin A1 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
  • All IHC stains will include a positive control tissue
  
  • Annexin A1 is used to differentiate hairy cell leukemia from other B-cell lymphomas including hairy cell leukemia variant. In the differential diagnosis of hairy cell leukemia and other B-cell neoplasms, Annexin A1 has a sensitivity of 96% and specificity of 100%. Consider using Annexin A1 as part of a panel of testing (BRAF, TRAP).
  • Annexin A1 is positive in normal T-cells and myeloid cells. Positivity has also been reported in T-cell leukemias/lymphomas, AML, CMML, CML, P. vera, ET, primary myelofibrosis, mast cell disease, carcinomas, and some sarcomas.
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

Tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

Annexin A1 is a protein encoded by the ANXA1 gene. The protein has multiple functions and is upregulated in hairy cell leukemia.
 
Staining pattern

Membranous and cytoplasmic



References

  1. Sherman MJ, Hanson CA, Hoyer JD. An Assessment of the usefulness of immunohistochemical stains in the diagnosis of hairy cell leukemia. Hematopathology 2011;136:390-399.
  2. Wang HY, Zu Y. Diagnostic algorithm of common mature B-cell lymphomas by immunohistochemistry Arch Pathol Lab Med 2017;14:1236-1246.
  
88342 - 1st stain
88341 - each additional stain
  
07/30/2019
  
07/30/2019
  
10/02/2020