Immediately following collection, mix by inverting 8 - 10 times to prevent clotting
Lavender (EDTA), 4mL
Lavender (EDTA), 4mL
Refrigerated - <72 hours
Ship same day if possible
RT-PCR and bi-directional sequencing of exons 14-17 of the SF3B1 gene
An interpretive report will be provided
SF3B1 mutations occur in 10-15% of CLL patients and serve as independent predictors of shortened time to treatment and poorer overall survival in CLL. Mutations are also detected in approximately 28% of MDS and 19% of myelodysplastic/myeloproliferative neoplasms. In MDS/MPN, most mutations were found in refractory anemia with ring sideroblasts (the RARS subtype).