HCG beta by IHC

Alphabetical Test listing

HCG beta by IHC-12376 - Technical only 12379 - Technical & interpretation

  
HCG beta by IHC
  
12376 - Technical only 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Human chorionic gonadotropin beta subunit
  
  • All IHC stains will include a positive control tissue
  
  • Gestational trophoblastic tumors (hydatiform moles and gestational choriocarcinomas) stain positively for HCG
  • Choriocarcinomas almost always stain positively for HCG
  • Syncytiotrophoblastic giant cells, when present in seminomas, embryonal carcinomas, endodermal sinus tumors and teratomas may stain positively for HCG
  • HCG positivity has also been reported in hepatoblastomas of childhood and carcinomas of the breast (up to 50% in some series), lung, gastrointestinal tract, ovary, uterus, and salivary glands
  • Bladder tumors may occasionally produce HCG (especially if they are of urachal origin)
  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Human chorionic gonadotropin (HCG) is a glycoprotein MWt 40,000) consisting of a protein core and a carbohydrate side chain. It is secreted in large quantities by the placenta, normally circulating at readily detectable levels only during gestation. Immunohistochemical studies reveal localization of HCG in syncytiotrophoblasts. (Occasionally, some mononuclear cytotrophoblasts show weak positivity for HCG. Although this may be the result of antigen leakage from adjacent syncytiotrophoblasts, one cannot exclude the possibility that HCG may also be elaborated by cytotrophoblasts.) A wide variety of tumors secrete HCG, however serum levels do not necessarily correlate with histologically demonstrable HCG

Staining patterns

  • Cytoplasmic based staining

  
88342 - 1st stain
88341 - each additional stain
  
05/15/2017
  
10/19/2018
  
10/02/2020