Microsatellite instability

Alphabetical Test listing

Microsatellite instability-Pathology add-on

Microsatellite instability
Pathology add-on

Analysis of MSI at 5 gene loci.

MSI PCR is often performed in conjunction with analysis of DNA mismatch repair enzymes by immunohistochemistry. Deficient DNA repair and MSI are associated with Lynch Syndrome, and may also be used to determine eligibility for drug therapy

Tumor tissue

Along with the tumor specimen, a normal control from the patient must be submitted.

The preferred normal control is a negative tissue block. If none is available, 5.0 mL of whole blood (ACD, EDTA or NaCitrate) may be submitted.


Formalin-fixed, paraffin-embedded (FFPE) tissue block


Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed


  • Improper label (unlabeled or mislabeled)
  • Improper storage
  • Interfering substances
  • Slides broken beyond repair
AHL - Molecular Diagnostics: D
7 days

Multi-plex Polymerase Chain Reaction (PCR) analyzed by capillary electrophoresis


An interpretative report will be included

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.