Red serum vial/tube, 5 mL

Gel-barrier tubes are not recommended.

1. Allow sample to clot
2. Spin
3. Transfer serum to a Serum/plasma transfer vial/tube (MedTox), labelled as serum, within two (2) hours of sample collection

Serum/plasma transfer vial/tube (MedTox)

Dk green heparin (Li or Na), no gel

Immediately following collection, mix sample by inverting 8 - 10 times to prevent clotting

1. Spin
2. Transfer plasma to aSerum/plasma transfer vial/tube (MedTox), labelled as the appropriate plasma type, within two (2) hours of sample collection

Refrigerated (preferred)

Ambient - <3 days

Frozen - OK

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Encainide: 15 - 100 ng/mL

ODE: 100 - 300 ng/mL

MODE: 60 - 300 ng/mL

Trough levels are most reproducible.

10% of patients do not form therapeutic concentrations of the active metabolites, ODE and MODE. In these patients the recommended range for the encainide concentration is 300 - 1200 ng/mL

Medical necessity