Paraneoplastic autoantibody evaluation

Alphabetical Test listing

Paraneoplastic autoantibody evaluation-8070

  
Paraneoplastic autoantibody evaluation
  
8070
  
LAB8070
  
PAE
  
Calcium channel blockers
Chorea
Cramp-fasciculation
Myoid Ab
Neuromyotonia
Ovarian cancer-related Abs
Paraneoplastic Abs
Isaacs disease
Alpha-3
  
  • Anti-neuronal nuclear Ab type 1
  • Anti-neuronal nuclear Ab type 2
  • Anti-neuronal nuclear Ab type 3
  • Anti-glial nuclear Ab type 1
  • Purkinje cell cytoplasmic Ab type 1
  • Purkinje cell cytoplasmic Ab type 2
  • Purkinje cell cytoplasmic Ab type Tr
  • Amphiphysin Ab  
  • CRMP-5-IgG
  • Striational (striated muscle) Ab
  • P/Q-type calcium channel Ab
  • N-type calcium channel Ab
  • AChR ganglionic neuronal Ab

Reflex testing when indicated performed at an additional charge:

  • ACh receptor (muscle) binding Ab
  • ACh Receptor (Muscle) modulating Ab
  • AGNA-1 immunoblot
  • AMPA-R Ab CBA
  • AMPA-R Ab IF titer assay
  • Amphiphysin immunoblot
  • ANNA-1 immunoblot
  • ANNA-2 immunoblot
  • CASPR2-IgG CBA
  • CRMP-5-IgG western blot
  • DPPX Ab CBA
  • DPPX Ab IFA
  • DPPX Ab IFA titer
  • GABA-B-R Ab CBA
  • GABA-B-R Ab IF titer
  • GAD65 Ab assay
  • LGI1-IgG CBA
  • mGIuR1 Ab CBA
  • mGIuR1 Ab
  • MGIuR1 Ab IFA titer
  • NMDA-R Ab
  • NMDA-R Ab titer
  • PCA-1 immunoblot
  • PCA-Tr immunoblot

Mayo Paraneoplastic Evaluation Algorithm

 

  
  • Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
  • Directing a focused search for cancer
  • Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
  • Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
  • Monitoring the immune response of seropositive patients in the course of cancer therapy
  • Detecting early evidence of cancer recurrence in previously seropositive patients
  
  • For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication
  • This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled if radioactivity remains
  • Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours
  
Serum
  
  
4.0 mL
  
2.0 mL
  
  1. Spin
  2. Transfer serum to a Screw cap transfer vial/tube (Mayo T914)
  
  
  

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambient - 72 hours

  
Mayo Clinic Laboratories (PAVAL/83380): R-MM
  
Daily
  
10 - 17 days
  

Immunofluorescence Assay (IFA)

Enzyme Immunoassay (EIA)

Radioimmunoassay (RIA)

Western Blot and Cell-binding assay (CBA)

Live cell assay (LCA)

  

See report

  
83519 x 4
86255 x 9
83520

Additional CPT codes (if appropriate):
83519 x 2
84182 x 7
86255 x 9
86256 x 5
86341
  
06/10/2004
  
02/18/2021
  
05/01/2020