This test should be ordered only if the specimen cannot be run at an Allina hospital lab within 30 minutes of collection. If the specimen can be run at an Allina hospital lab within 30 minute of collection, order the Beta Hydroxybutyrate, whole blood (in-house).
In-house whole blood testing is available at the Central Laboratory, Buffalo, Cambridge, District One, Mercy, New Ulm, Owatonna, Regina, River Falls, St. Francis, Unity, United hospitals, and WestHealth.
Note differing specimen collection/transport requirements.
The β-hydroxybutyrate assay will not detect acetoacetic acid and acetone. Acidosis shifts equilibrium toward β-hydroxybutyrate, but treatment of ketoacidosis results in increased acetoacetate and a more positive "acetone" reaction before ketone bodies decrease.
Patient should be fasting
Frozen (preferred) - 11 days
Ambient - 8 hours
Refrigerated - 2 days
All ages (fasting): 0.2 - 2.8 mg/dL
Beta-Hydroxybutrate is one of 3 sources of ketone bodies. Ketoacidosos in diabetes usually occurs with decreased plasma pH and bicarbonate, increased glucose and other abnormalities. As ketoacidosis and metabolic acidosis are treated, hypokalemia may become evident. A normal or low potassium on admission with ketoacidosis may indicate severe potassium depletion. Thus, potassium is among parameters to follow in treatment of ketoacidosis. In children younger than 10 years of age, diabetic ketoacidosis is reported to account for 70% of diabetes-related deaths.