Cadherin 17 by IHC

Alphabetical Test listing

Cadherin 17 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Cadherin 17 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Intestinal peptide-associated transporter
HPT-1 Liver-intestine cadherin
  
  • All IHC stains will include a positive control tissue
  
  • Cadherin 17 is a highly specific marker for colon cancer, and is more sensitive (99% sensitivity) than CDX2 (89%)
  • Cadherin 17 may help identify early Barrett's esophagus and is positive in esophageal adenocarcinomas (67-82%); it is more sensitive than CDX2 in labelling esophageal adenocarcinomas (75 vs 69%)
  • Cadherin 17 has been reported in 23-90% of gastric adenocarcinomas; it is less sensitive than CDX2 in labelling gastric adenocarcinomas (44 vs. 62.5%)
  • Cadherin 17 has been identified in 18-82% of primary pancreatic ductal adenocarcinomas, and in 40% of metastatic pancreatic ductal adenocarcinomas (and is more sensitive than CDX2)
  • Most neuroendocrine tumors of the small intestine and colon have been reported to stain positively for Cadherin 17
  • This marker can help distinguish between primary urinary bladder carcinoma (Cadherin 17 positive) from urothelial carcinoma with glandular differentiation
  • Cadherin 17 has been also identified in tumors of the bladder (adenocarcinomas), lung, endometrium, uterine cervix and ovary (CK7 and CK20 can help separate many of these from GI tumors)
  • This marker is also a sensitive (81%) and highly specific (100%) marker for metanephric adenoma
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Cadherin 17 is an oncogene involved in tumor invasion and metastasis and is a cell adhesion molecule
  • Cadherin 17 is exclusively expressed in normal epithelial cells of small intestine, colon and pancreatic ducts; it is not seen in liver (except in intrahepatic bile ducts) and stomach (except in areas of intestinal metaplasia)
  • It is more sensitive than CDX2 in identifying tumors of colorectal or esophagus origin. However, it is less sensitive than CDX2 in labeling tumors of stomach origin

Staining patterns

  • Membranous staining

References

  1. Ordonez NG: Cadherin 17 is a novel diagnostic marker for adenocarcinomas of the digestive system. Adv Anat pathol 2014; 21(2): 131-137.
  2. Rao Q et al: Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers. Mod Pathol 2013; 26: 725-732.
  3. Su MC et al: Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol 2008;21:1379-1386.
  4. Yakirevich E, et al: Cadherin 17 is a sensitive and specific marker for metanephric adenoma. Am J Surg Pathol 2015;39:479-486.
  
88342 - 1st stain
88341 - each additional stain
  
05/15/2017
  
10/17/2018
  
10/02/2020