CD1a by IHC

Alphabetical Test listing

CD1a by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
CD1a by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Leu-6
OKT6
SKg
T6
  

All IHC stains will include a positive control tissue

  
  • CD1a can be used in conjunction with S-100 to differentiate between the various malignant and benign histiocytic proliferations:
  CD1a S-100
Langerhans cells (LC)* + +
Interdigitating cells - +
Dendritic Reticulum cells - +

* This pattern of staining is seen in both benign (e.g. dermatopathic lymphadenopathy) and malignant (histiocytic) LC proliferations. However, LC's in histiocytosis X have been found to be CD4 positive, while benign LC's are CD4 negative.

 

  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • CD1a is a 49kDa cell surface glycoprotein found on human Langerhans cells and thymocytes, but not on peripheral T-cells

Staining pattern

  • Cell membrane and/or diffuse cytoplasmic

References

  1. Ornvold et al, Virchows Archiv-A, 416(5):403-10, 1990.
  2. Shamoto et al, Advances in Exp. Med & Biology, 378:139-41, 1995.
  
88342 - 1st stain
88341 - each additional stain
  
05/15/2017
  
10/17/2018
  
10/02/2020