Everolimus

Alphabetical Test listing

Everolimus-13477

  
Everolimus
  
13477
  
LAB13477
  
EVER
  
Afinitor
Certican
Everolimus, whole blood
Zortress
  

Everolimus is a proliferation signal inhibitor that prevents allograft rejection. It exerts its immunosuppressive effect by inhibiting the proliferation, and thus clonal expansion, of antigen-activated T-cells, which is driven by T-cell-specific interleukins. Everolimus inhibits an intracellular signaling pathway that is triggered up binding of these T-cell growth factors to their respective receptors, and which normally leads to cell proliferation. The blockage of this signal by everolimus leads to an arrest of the cells at the G1 stage of cell cycle.

  

Trough levels are most reproducible

  
EDTA whole blood
  
  
2.0mL
  
0.5mL
  

Lavender (EDTA), 4mL

  
Heparin whole blood
  

Dk green heparin (Li or Na), no gel

  

  

Dk green heparin (Li or Na), no gel

  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

  
LabCorp Burlington (700003): R-LC
  
Daily
  
2 - 4 days
  

Liquid chromatography/tandem mass spectometry (LC-MS/MS)

  

3.0 - 8.0 ng/mL

  
80169
  
03/29/2019
  
10/11/2021
  
02/22/2021