Trisomy 12/ 13q14 by FISH
Trisomy 12/ 13q14 by FISH-4280G (bone marrow) or 4280H (blood)
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
Trisomy 12
+12
FISH
Fluorescence In Situ Hybridization
Trisomy 12 is a recurring abnormality of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). According to current NCCN CLL guidelines, trisomy 12 is classified as an intermediate cytogenetic risk factor.
This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (See the individual panel tests for more details).
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
- Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
- Immediatley following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Heparinized whole blood
Touch prep slides
Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
Whole blood:
Dk green Sodium heparin (Na hep), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.
Submit entire specimen unspun
Bone marrow core:
Sterile vial/tube
Whole Blood:
Dk green Sodium heparin (Na hep), no gel
AHL Cytogenetics oncology request
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Delay in transport
- Improper storage
- Leaking container
- Slides broken beyond repair
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.