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HER2 Fluorescence in Situ Hybridization (FISH)

HER2 is a gene that can become amplified in several types of cancers, including breast, gastric, esophageal and lung to name a few.

A normal result would show cells with only 2 copies of both HER2 and centromere 17,  a HER2 copy: centromere 17 copy ratio of <2.0.

An abnormal amplified HER2 (red signal) to centromere 17 (green signal) ratio test result.