Alzheimer's Disease Evaluation Profile, CSF
Alzheimer's Disease Evaluation Profile, CSF-16207
This assay requires a special tube at collection
AD Evaluation
pTau-181
tTau/Abeta42 Ratio
pTau-181/Abeta42 Ratio
Total Tau (tTau)
Phospho‑Tau 181 (pTau-181)
These values are used to calculate the tTau/Abeta42 Ratio and the pTau-181/Abeta42 Ratio
Used to evaluate adult patients aged 55 years and older for Alzheimer's disease (AD) and other causes of cognitive impairment to generate a tTau/Abeta42 ratio value1,2 and a pTau-181/Abeta42 ratio value
The Abeta42, tTau and pTau-181 assays are not intended to be used as standalone tests and should only be used to calculate the tTau/Abeta42 and pTau-181/Abeta42 ratios.
- This specific tube is required
- Use of a different collection container can affect results
Perform lumbar puncture (LP) using gravity drip collection method.
• Avoid the use of syringes or tubings.
• Perform lumbar puncture (LP) before noon.
Do not use the first 2 mL of CSF for AD Biomarker measurement.
Subsequently, collect at least 1.0 mL of CSF directly into the CSF tube 63.614.625 (Sarstedt) for AD biomarker measurements.
• (Note: The mark on the tube indicates 2.5 mL.)
• Each sample should be visually inspected for hemolysis.
• Do not use CSF samples that appear reddish for measurement of Elecsys AD biomarkers.
Do not process the CSF sample before transport to the measuring site (i.e., no mixing/inverting, no tube transfers, no aliquoting, no freezing and normally no centrifugation) until measurement.
Sarstedt CSF Tube
Refrigerated (preferred) - 14 days
Ambient - 5 days
Frozen - 8 weeks
- Hemolyzed CSF samples that are visibly colored red
- Samples received in any tube other than Sarstedt CSF tube (including the Liquor tube)
Roche Diagnostics Electrochemiluminescence Immunoassay (ECLIA)
An interpretive report will be provided