TP53 mutation

Alphabetical Test listing

TP53 mutation-994

Test name:

TP53 mutation

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

P53
CLL
BCLL
TP53 gene somatic mutation analysis

Useful for:

Evaluating chronic lymphocytic leukemia patients at diagnosis or during disease course for the presence of TP53 gene variants indicating high risk of disease progression and adverse outcomes.

This test is not intended for the evaluation of patients suspected of having an inherited or germline TP53 cancer syndrome (eg, Li Fraumeni syndrome)

Specimen type:

EDTA whole blood

Collection container:

Volume:

3 mL

Minimum volume:

1 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

Processing instructions:

Send whole blood specimen in original tube. Do not aliquot.

Required forms/information:

Molecular Hematopathology Patient Information

Molecular Medicare Billing Request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Transport and stability:

Refrigerated (preferred) - 10 days

Ambient - 10 days

Specimen retention time:

2 weeks

Reason for rejection:

Gross hemolysis
Extracted DNA
Moderately to severely clotted

Performing lab:

Mayo Clinic Laboratories (P53CA): R-NX

Days set up:

Mo - Fr

TAT:

8 -14 days

Method:

Polymerase Chain Reaction (PCR) and Sanger Sequencing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81352

Other billing information:

Medical necessity

Molecular Medicare Billing Request

Date created:

03/13/2023

Revised date:

05/23/2024

Review date:

03/14/2023