Alpha-Synuclein Protein Aggregates, Spinal Fluid

Alphabetical Test listing

Alpha-Synuclein Protein Aggregates, Spinal Fluid-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

SAAmplify-aSYN
SYNTap
Amprion
Alpha-Synuclein Aggregates
Parkinson Disease (PD)
Dementia with Lewy bodies (DLB)
Lewy body disease (LBDCSF)
Alzheimer disease (AD)
Mild cognitive impairment (MCI)
Multiple system atrophy (MSA)
RT-QuIC
Seed Amplification Assay (SAA)
Synucleinopathy
AMP1200

Useful for:

Detection of pathogenic alpha-synuclein (alpha-synuclein aggregates) in adult patients being assessed for clinically uncertain cognitive decline or clinically uncertain parkinsonian syndromes

Specimen type:

Cerebrospinal fluid (CSF)

Collection container:

Screw-capped polypropylene vial/tube, sterile (Mayo)

Volume:

1.0 mL

Minimum volume:

0.3 mL

Collection instructions:

Perform lumbar puncture and discard the first 1 to 2 mL of cerebrospinal fluid (CSF).
Collect CSF directly into a sterile polypropylene tube.
Freeze sample upright

Processing instructions:

Inspect specimen for visible discoloration.Specimen must be clear and colorless to perform testing.
Do not centrifuge

Transport container:

Screw-capped polypropylene vial/tube, sterile (Mayo)

Transport and stability:

Frozen (preferred) - 60 days

Refrigerated - 14 days

Reason for rejection:

Hemolysis
Icterus
Unclear/discolored specimen
Specimens not collected in polypropylene collection tubes

Performing lab:

Amprion Inc via Mayo Clinic Laboratories (ASYNC)

Days set up:

Varies

TAT:

15 - 18 days

Method:

Seed Amplification Assay (SAA)

Reference ranges:

An interpretive report will be provided

Cautions:

Results must be interpreted in conjunction with other patient clinical information.

CPT codes:

0393U

Date created:

05/05/2025

Review date:

05/05/2025