Celiac Ab TTG TIGA w/rflx
Celiac Ab TTG TIGA w/rflx-12442
Celiac disease panel
Celiac
TTG
DGP
Celiac Antibodies tTG IgA and Total IgA With Reflex to tTG IgG and DGP IgG
- Total IgA and tTg IgA
- Deamidated Gliadin IgG and tTG IgG performed at an additional charge, if indicated
Celiac disease is characterized by gluten intolerance leading to a chronic malabsorptive disorder due to inflammation of the intestinal mucosa and flattening of the epithelium. Autoantibodies associated with celiac disease include; IgA anti-endomysial antibodies, IgG and IgA anti-gliadin antibodies and anti-reticulin antibodies. Several studies have demonstrated that IgA anti-endomysial tests have greater than 99% specificity for celiac disease with a greater sensitivity than anti-gliadin and anti-reticulin assays.
Immediately following collection, thoroughly mix sample by gently inverting 5 times
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Gold serum separator (SST) tube
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
- Hemolysis
- Lipemia
- Gross bacterial contamination
Enzyme immunoassay (EIA)
IgA total
Adult: 87 - 352 mg/dL
TTg IgA
Negative: 0 - 3 U/mL
Weak positive: 4 - 10 U/mL
Strong positive: >10 U/mL
TTg IgG
Negative: 0 - 5 U/mL
Weak positive: 6 - 9 U/mL
Strong positive: >9 U/mL
Gliadin IgA
Negative: 0 - 19 U/mL
Weak positive: 20 – 30 U/mL
Strong positive: >30 U/mL
Additional CPT codes (if appropriate):
86258 - Gliadin Ab IgA
86258 - Gliadin Ab IgG
86364 - Tissue Transglutaminase IgA
86364 - Tissue Transglutaminase IgG
17027680 - Gliadin Ab IgA
17029456 - Gliadin Ab IgG
17027678 - Tissue transglutaminase IgA
17027679 - Tissue transglutaminase IgG
308625801 - Gliadin Ab IgA
308625800 - Gliadin Ab IgG
308636400 - Tissue transglutaminase IgA
308636401 - Tissue transglutaminase IgG