N-methyl-D-aspartate receptor antibody, IgG, CSF

Alphabetical Test listing

N-methyl-D-aspartate receptor antibody, IgG, CSF-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Anti-N-methyl-D-Aspartate Receptor (NMDAR), Spinal Fluid
Anti-NMDA CSF
anti-NR1
Glutamate receptor antibodies
N-methyl D-aspartate Ab CSF
NMDA R
NMDAR
NMDA receptor Ab CSF

Tests included:

If NMDA antibody IgG is positive, then a NMDA antibody is reported.

Useful for:

Confirm diagnosis of anti-NMDAR encephalitis.
May be used in monitoring treatment response in individuals who are antibody positive.

Specimen type:

Cerebrospinal fluid (CSF)

Collection container:

Sterile screw cap vial/tube - 15mL (LabCorp)

Volume:

2.0 mL

Minimum volume:

1.0 mL

Transport container:

Sterile screw cap vial/tube - 15mL (LabCorp)

Transport and stability:

Ambient (preferred) – 2 weeks

Refrigerated – 2 weeks

Frozen – 2 weeks

Freeze/thaw cycles - stable x3

Reason for rejection:

Contaminated specimen
Hemolysis
Severe lipemia

Performing lab:

LabCorp (505720): R-NX

Days set up:

Su - Sa

TAT:

4 days

Method:

Immunofluorescence, Immunoblot

Reference ranges:

See report

Clinical information:

Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

CPT codes:

86255
86256 (if indicated)

Date created:

05/05/2020

Revised date:

03/26/2024

Review date:

03/26/2024