Signal Recognition Particle

Alphabetical Test listing

Signal Recognition Particle-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

SRP
Anti-SRP Ab

Useful for:

SRP is considered a Myositis-specific antibody. It is commonly found in Polymyositis, ILD and arthritis, and occasionally in dermatomyositis. Anti-SRP was first described in a polymyositis patient in 1986. Anti-SRP antibodies are rare, in only about 4% of myositis patients, and are often found in African American females with an acute, severe onset of polymyositis, with poor response to therapy.

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

1.0 mL

Minimum volume:

0.3 mL
(Note: This volume does not allow for repeat testing.)

Collection instructions:

Immediatley following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within one (1) hour of sample collection
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Alternate collection container:

Red serum vial/tube - 5 mL

Alternate processing instructions:

Allow sample to clot
Spin within one (1) hour of sample collection
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Transport and stability:

Refrigerated (preferred) - 14 days

Ambient - 7 days

Frozen - 60 days

Reason for rejection:

Grossly hemolyzed
bacterial contamination
lipemic specimen
icteric specimen

Performing lab:

LabCorp (520014): R-NX

Days set up:

Weekly

TAT:

14 - 21 days

Method:

RIPA gel radiography

Reference ranges:

Negative

The presence of SRP antibodies is predominantly associated with polymyositis. The prevalence of SRP antibodies in idiopathic inflammatory myopathy is 4-5%

CPT codes:

83516

Date created:

05/23/2019

Revised date:

02/02/2021

Review date:

08/16/2023