Apolipoprotein B
Apolipoprotein B-13422
Beta apolipoprotein
β apolipoprotein
LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.
Patient should fast 12 - 14 hours prior to specimen collection
- Allow sample to clot
- Spin within two (2) hours of sample collection
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
Heparin plasma
Gold:
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Lavender/Dk green:
- Spin within two (2) hours of sample collection
- Transfer plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as the appropriate plasma type
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x 3
- Specimen from nonfasting patient
Immunologic
Desirable: < 90 mg/dL
Borderline High: 90 - 99 mg/dL
High: 100 - 130 mg/dL
Very High: > 130 mg/dL