IgG by IHC

Alphabetical Test listing

IgG by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

IgG by IHC

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

Immunoglobulin G

Tests included:

All IHC stains will include a positive control tissue

Useful for:

IgG labels plasma cells
IgG stains will show an interstitial dendritic pattern within lymphoid follicles, (this represents extracellular immune complexes which are bound to the surface of specialized follicular dendritic cells)
IgG will label occasional B cell lymphomas

Limitations:

When ordering as Technical with Intrepretation, both IgG by IHC and IgG4 by IHC must be ordered together

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin-embedded tissue

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications:

This antibody reacts with heavy chains (gamma) of human IgG (Fc-part)
This antibody labels plasma cells and various lymphocytes

Staining pattern:

Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)

References

Taylor CR et al: The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol 1974; 27:14-20.
Taylor CR et al: The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immunoperoxidase technique. Clin exp Immunol 1974; 8:417-29.

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

07/03/2017

Revised date:

10/19/2018

Review date:

01/12/2024