CMV Resistance: Ganciclovir, Foscarnet, Cidofovir

Alphabetical Test listing

CMV Resistance: Ganciclovir, Foscarnet, Cidofovir-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

CMV drug resistance
CMV resistance
UL54
UL97

Tests included:

Ganciclovir UL97
Cidofovir UL54
Foscarnet UL54
Ganciclovir UL54

Useful for:

Detecting variants in the cytomegalovirus genes, UL97 and UL54, which are associated with antiviral resistance

Specimen type:

EDTA plasma

Collection container:

Lavender (EDTA), 4mL

Volume:

2.0 mL

Minimum volume:

0.5 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Processing instructions:

Spin within two (2) hours of sample collection
Transfer plasma to a Screw cap transfer vial/tube (Mayo T914), labelled as EDTA plasma

Transport container:

Screw cap transfer vial/tube (Mayo T914)

Alternate specimen type:

ACD plasma

Alternate collection container:

Yellow ACD (A or B)

Transport and stability:

Ambient (preferred) - 7 days

Refrigerated - 7 days

Frozen - 60 days

Specimens shipped at ambient temperature must be received within 96 hrs. of collection.

Reason for rejection:

Gross hemolysis, lipemia or icterus
CMV concentrations to low to allow antiviral resistance testing
Frozen whole blood

Performing lab:

Viracor via Mayo Clinic Laboratories (FCMVR): R-NX

Days set up:

Mo - Sa

TAT:

4 - 10 days

Method:

Conventional PCR followed by genotypic sequencing

Reference ranges:

None detected

CPT codes:

87910 x2

Date created:

01/02/2024