Erythrocytosis evaluation, whole blood

Alphabetical Test listing

Erythrocytosis evaluation, whole blood-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

BPGM
Chuvash Polycythemia
Congenital erythrocytosis
Congenital polycythemia
EGLN1
EPAS1
EPOR
Erythrocytosis
Familial erythrocytosis
Familial polycythemia
PFCP
Hereditary erythrocytosis
Hereditary polycythemia
HIF2
High oxygen affinity hemoglobin
HOA hemoglobin
PHD2
Polycythaemia
Polycythemia
Primary familial erythrocytosis
Primary familial polycythemia
VHL

Tests included:

Hb Variant, A2 and F Quantitation, B
HPLC Hb Variant, B
Hb Variant by Mass Spec, B

Useful for:

Definitive, comprehensive, and economical evaluation of an individual with JAK2-negative erythrocytosis associated with lifelong sustained increased hemoglobin or hematocrit

Limitations:

Polycythemia vera and acquired causes of erythrocytosis should be excluded before ordering this evaluation.

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

5.0 mL

Minimum volume:

2.5 mL

Collection instructions:

Immediatley following collection, mix samples thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Processing instructions:

Refrigerate specimens immediately after collection
Do not aliquot

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Yellow ACD-B whole blood
Sodium heparin (Na hep) whole blood

Alternate collection container:

Yellow ACD-solution B (ACD-B) vial/tube

Transport and stability:

Refrigerated – 7 days

Ambient - NO

Frozen - NO

Specimen retention time:

28 days

Reason for rejection:

Gross hemolysis

Performing lab:

Mayo Clinic Laboratories (REVE2): R-NX

Days set up:

Mo - Sa

TAT:

3 - 25 days

Method:

REVEI, REVE0: Medical Interpretation
HGBCE: Capillary electrophoresis
HPLC: Cation Exchange/High Performance Liquid Chromatography (HPLC)
MASS: Mass Spectrometry (MS)
IEF: Isoelectric Focusing
UNHB Isopropanol and Heat Stability
VHLE: Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

Reference ranges:

Definitive results and an interpretive report will be provided.

Clinical information:

Erythrocytosis Evaluation.indd (mayocliniclabs.com)

CPT codes:

83020 - Hemoglobin Electrophoresis
83021 - HPLC Hb Variant
83789 - Hemoglobin Variant by Mass Spectroscopy (MS), Blood

Additional CPT codes (if appropriate):
83068
82664
88184

Date created:

08/12/2021

Revised date:

03/25/2025

Review date:

03/25/2025