ATM/TP53 by FISH
ATM/TP53 by FISH-4280G (bone marrow) or 4280H (blood)
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
FISH
Fluorescence in situ hybridization
SLL
Small Lymphocytic lymphoma
ATM
TP53
TP53 Deletion
11q-
11q22
17p13.1
Deletion of 11q22 (ATM) and 17p13.1 (TP53) are recurring abnormalities of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). ATM/TP53 FISH testing is useful in the cytogenetic prognosis of CLL/SLL.
This test can be ordered individually or as part of a CLL Full Panel, CLL Prognostic Panel, or CLL Progressive Panel. See the individual panel tests for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
- Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
- Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Whole blood
Touch Prep Slides
Bone Marrow Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
or
Whole blood:
Dk green Sodium heparin (Na hep), no gel
Whole blood: 4 mL
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Delay in transport
- Improper storage
- Leaking container
- Slides broken beyond repair
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.