MLL (CDKN2A) by FISH
MLL (CDKN2A) by FISH-4280G (bone marrow) or 4280H (blood)
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
B-ALL
B-cell ALL
FISH
Fluorescence in situ hybridization
Mixed Lineage Leukemia
MDS
Myelodysplastic syndrome
t(11q23;?)
AML
Acute Myeloid Leukemia
CDKN2A
MLL (CDKN2A) or t(11q23;?) rearrangements are recurring abnormalities in AML, B-cell ALL and MDS. According to current NCCN AML guidelines, these abnormalities are classified as adverse cytogenetic risk factors, however, a t(9;11) is classified as an intermediate risk factor. All MLL rearrangements are classified as intermediate cytogenetic risk factors in MDS.
This test can be ordered individually or as part of the B-ALL or MDS FISH Panels. See the panel tests for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Sodium heparinized whole blood
Touch Prep slides
Bone marrow core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
Whole blood:
Dk green Sodium heparin (Na hep), no gel - 4mL
Whole blood: 5 mL
Submit entire specimen unspun
AHL Cytogenetics Oncology Requisition
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Delay in transport
- Improper storage
- Leaking container
- Slides broken beyond repair
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation