Alpha-fetoprotein (AFP) tetra profile

Alphabetical Test listing

Alpha-fetoprotein (AFP) tetra profile-13498

Test name:

Test number:

13498

Excellian order number:

LAB13498

Abbreviation:

AFPT

Alternate names:

AFP
AFP tetra
α-fetoprotein (AFP) tetra profile
Quad screen

Tests included:

α-Fetoprotein, serum; dimeric inhibin A (DIA); human chorionic gonadotropin (hCG); unconjugated estriol (uE3)

Useful for:

Screening test for

Open Spina Bifida/ONTD (detects 80% Open Spina Bifida, 90% anencephaly)
Trisomy 21/Down syndrome (detects 75 - 80%
Trisomy 18/Edward's syndrome (detects 73%)

Patient preparation information:

The gestational age for collection of the AFP tetra profile is 15.0 - 21.9 weeks for Downs syndrome, and 15.0 - 23.9 for Open Spina Bifida (optimal GA for Open Spina Bifida 16.0 - 18.9 weeks).

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

5.0 mL

Minimum volume:

3.0 mL

Collection instructions:

Specimens must be collected before amniocentesis.

Immediatley following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within two (2) hours of sample collection

Pour off is not advised.

Transport container:

Serum separator (Gold SST) tube

Required forms/information:

Maternal testing clinical information form

Transport and stability:

Ambient (preferred) - 7 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

Reason for rejection:

Gross hemolysis
Gross lipemia
quantity not sufficient for analysis (QNS)
Improper specimen type

Performing lab:

LabCorp RTP (017319): R-LC

Days set up:

Mo - Sa

TAT:

2 - 5 days

Method:

Chemiluminescent immunoassay

Reference ranges:

An interpretive report will be provided

CPT codes:

86336
84702
82105
82677

Subject to medical necessity (Y/N):

Yes

LCD/NCD:

Medical necessity

LOINC code:

Result 49092-0

Date created:

04/08/2019

Revised date:

01/02/2024

Review date:

01/02/2024