IgG4 by IHC

Alphabetical Test listing

IgG4 by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

IgG4 by IHC

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

Immunoglobulin

Tests included:

All IHC stains will include a positive control tissue

Useful for:

Elevated serum IgG4 levels may be associated with localized or systemic allergic and autoimmune manifestations, such as inflammatory pseudotumor in liver, breast, and lung, sclerosing pancreatitis, and pemphigus vulgaris
In these disease states, increased numbers of IgG4-positive plasma cells are present in the tissue

Limitations:

When ordering as Technical with Intrepretation, both IgG by IHC and IgG4 by IHC must be ordered together

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin-embedded tissue

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

Immunoglobulin function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system.
IgG represents one of the immunoglobulin heavy chain types
IgG4 is the least abundant of IgG subclasses, normally comprising 6% of total IgG

Staining pattern

Cytoplasmic

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

10/30/2017

Revised date:

10/19/2018

Review date:

01/12/2024