Human placental lactogen by IHC

Alphabetical Test listing

Human placental lactogen by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

HPL

Tests included:

All IHC stains will include a positive control tissue

Useful for:

HPL is used to identify syncytiotrophoblastic cells of choriocarcinoma
HPL is positive in placental site trophoblastic tumors (these tumors can also be focally positive for bHCG)
HPL will also stain placental site nodules
HPL can identify the implantation site throughout gestation

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin-embedded tissue

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

Anti - HPL (also known as human chorionic somatomammotropin) identifies intermediate trophoblasts, and syncytiotrophoblasts

Staining pattern

Cytoplasmic staining

References

Kurman RJ et al: Immunocytochemical localization of HPL and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol 1984;3:101-121.

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

07/03/2017

Revised date:

10/19/2018

Review date:

01/12/2024