CD4 by IHC
CD4 by IHC-12376 - Technical only, 12379 - Technical & interpretation
CD4 by IHC
12376 - Technical only, 12379 - Technical & interpretation
LAB12376
LAB12379
LAB12379
All IHC stains will include a positive control tissue
- Is used to identify helper T cells
- This antibody is expressed on most mature T-cell lymphomas (except aggressive NK cell leukemia, extranodal NK cell lymphoma, gamma delta T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma and enteropathy-type T-cell lymphoma)
- CD4 can be seen on some T-lymphoblastic lymphomas
- This antibody is used in a panel with other T cell markers, to assess antigen expression relationships of benign and malignant T cell populations; unexpected expression and or loss of CD4 can occur in neoplasms
- CD4 is often used with CD8 to evaluate helper/suppressor relationships of T lymphocytes
Tissue
Submit a formalin-fixed, paraffin-embedded tissue
Formalin-fixed, paraffin-embedded (FFPE) tissue block
FFPE tissue section mounted on a charged, unstained slide
Ambient (preferred)
- Unlabeled/mislabeled block
- Insufficient tissue
- Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days
Immunohistochemical staining and microscopic examination
If requested, an interpretive report will be provided
Specifications
- The CD4 molecule interacts with the HLA class II during antigen recognition
- CD4 antibody reacts with the CD4 protein associated with the helper subset of T lymphocytes
- CD4 is present in the majority of thymocytes
- CD4 also is present on various monocytic cells, such as Langerhans' cells, and other dendritic cells
Staining pattern
- Cell surface membrane staining
References
- Macon WR, et al: T-cell subset analysis of peripheral T-cell lymphomas by paraffin section immunohistology and correlation of CD4/CD8 results with flow cytometry. Am J Clin Pathol, 109:610-617, 1998.
88342 - 1st stain
88341 - each additional stain
88341 - each additional stain
05/15/2017
10/18/2018
01/12/2024