Fluphenazine is a phenothiazine derivative (piperazine) used in the treatment of psychotic disorders
Immediatley following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Therapeutic: 1.0-10.0 ng/mL
Its dose in milligrams equivalent to 100 mg of chlorpromazine is 0.6-1.2 mg. A statistical evaluation1 of clinical studies found the near maximal effective dose of oral fluphenazine to be <6.9 mg/day. For the decanoate, the near-maximal effective dose was 25 mg/two weeks. As a high potency antipsychotic, it may have a high potential for causing extrapyramidal side effects. This would be in addition to the usual adverse effects of antipsychotic drugs (neurologic, anticholinergic, hypotension). Elderly patients should be observed for these occurrences. The half-life of fluphenazine is formulation-dependent. (The decanoate is 5 to 12 days; the hydrochloride 12 to 60 hours.) Fluphenazine is also used to alleviate pain and in childhood development disorders.