Bielschowsky Silver stain

Alphabetical Test listing

Bielschowsky Silver stain-12376 - Technical only, 12379 - Technical & interpretation

Test name:

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

Alzheimer
Nerve fibers
Neurofibrillary tangles
Senile plaques
Special stain

Tests included:

All special stains will include a positive control tissue

Useful for:

This procedure is used for the demonstration of nerve fibers and the presence of neurofibrillary tangles and senile plaques in Alzheimer disease.

As aging occurs, most individuals develop alteration of neurofibrils in at least some neurons; the neurofibrils may become clumped or twisted. In Alzheimer disease, tremendous numbers of the neurofibrillary tangles develop.

Specimen type:

Tissue

Collection container:

Formalin vial/container

Processing instructions:

Prepare a formalin-fixed, paraffin-embedded (FFPE) tissue block

Transport container:

FFPE tissue block

Alternate processing instructions:

Prepare two (2) 8 micron thick section unstained positively charged slides from an FFPE tissue block

Alternate transport container:

Slides in a Slide holder - 5 specimen

Required forms/information:

Histopathology Processing & Special Stains requisition

Transport and stability:

Ambient

Protect paraffin block and/or slides from excessive heat

Reason for rejection:

Insufficient tissue in block
Mislabeled/Unlabeled block or slides
Broken slides

Performing lab:

AHL - Histology: A

Days set up:

Mo - Fr

TAT:

24 - 48 hours

Method:

Histochemical staining and microscopic evaluation

Reference ranges:

An interpretive pathology report will be provided for Technical with Interpretation cases.

CPT codes:

88313

Date created:

06/29/2021

Review date:

01/12/2024