Y chromosome microdeletion

Alphabetical Test listing

Y chromosome microdeletion-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Tests included:

Five common Y chromosome microdeletions:

AZFa
AZFb
AZFc
AZFbc
AZFabc

Useful for:

Aids in determining the cause of azoospermia or oligospermia
Helps predict effectiveness of assisted reproductive technologies in men with Y chromosome microdeletions

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

2.0 mL

Minimum volume:

1.0 mL

Collection instructions:

Immediatley following collection, mix sample by inverting 8 - 10 times to prevent clotting

Processing instructions:

Submit tube unspun

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

ACD whole blood

Alternate collection container:

Yellow ACD (A or B)

Alternate transport container:

Yellow ACD (A or B)

Required forms/information:

Molecular Medicare Billing Request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Transport and stability:

Refrigerated (preferred) – 1 month

Ambient – 1 week

Frozen - NO

Performing lab:

ARUP (2001778) via LabCorp (009985): R-NX

Days set up:

Varies

TAT:

8 - 10 days

Method:

Polymerase Chain Reaction/Electrophoresis

Reference ranges:

See report

Clinical information:

Y chromosome microdeletions are typically characterized by azoospermia, severe to moderate oligospermia, or abnormal sperm morphology/motility in men with a normal physical evaluation. Assisted reproductive techniques are contraindicated for men carrying AZFa, AZFb, AZFbc or AZFabc microdeletions, which are classically associated with spermatogenic failure.

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81403

Other billing information:

Medical necessity

Molecular Medicare Billing Request

Date created:

10/12/2020

Revised date:

05/23/2024

Review date:

12/18/2023