MPL mutation analysis

Alphabetical Test listing

MPL mutation analysis-13552

  
MPL mutation analysis
  
13552
  
LAB13552
  
MPL
  
Myeloproliferative leukemia oncogene homology
  

MPL W515 mutations are present in patients with primary myelofibrosis (PMF) and essential thrombocythemia (ET) at a frequency of approximately 5% and 1% respectively. The S505 mutation is detected in patients with hereditary thrombocythemia.

  
EDTA whole blood
  
  
5.0 mL
  
3.0 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

  

Lavender (EDTA) tube

  
Sodium heparin (Na hep) whole blood
Bone marrow cell pellet
  
  
Bone marrow cell pellet - 2.0 mL (minimum 1.0 mL)
  

Dk green Sodium heparin (Na hep), no gel

Sterile vial/container

  

Molecular Medicare Billing Request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

  

Ambient

If specimen is to be stored prior to shipment, store at 2 - 8°C.

  
  • Specimen does not meet collection criteria
  • frozen whole blood, marrow, or cell pellet
  • leaking tube
  • clotted blood or marrow
  • grossly hemolyzed specimen or otherwise visibly degraded
  • contamination by another specimen
  • specimens containing suspicious foreign material
  
LabCorp RTP (489150): R-LC
  
Mo - Fr
  
7 - 12 days
  

Polymerase chain reaction (PCR) and DNA sequencing

  

An interpretive report will be provided

  

MPL (myeloproliferative leukemia virus oncogene homology) belongs to the hematopoietin superfamily and enables its ligand thrombopoietin to facilitate both global hematopoiesis and megakaryocyte growth and differentiation.

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81338
  
Yes
  
Result 62947-7
  

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare Billing Request

  
04/10/2019
  
05/23/2024
  
01/02/2024