IgD by IHC

Alphabetical Test listing

IgD by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

IgD by IHC

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

Anti-human IgD

Tests included:

All IHC stains will include a positive control tissue

Useful for:

In paraffin tissue, the antibody labels plasma cells with IgD
IgD labels B cell lymphocytes in primary follicles
In secondary follicles, the staining is in the mantle zone with coarse meshwork of IgD in the germinal centers (this represents immune complexes present on the surface of dendritic reticulum cells

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin-embedded tissue

Transport container:

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

The antibody reacts with the heavy chain (delta chain) of human IgD
This antibody labels plasma cells, and various lymphocytes (the later depends on the methodology - i.e. frozen vs. paraffin)

Staining pattern

Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)

References

Mason DY et al: Blood 1987; 69:836-40.
Falini B et al: Histopathology 1986; 10:671-87.
Erber WN et al: Lancet 1986; 1:761-5.

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

10/30/2017

Revised date:

10/19/2018

Review date:

01/12/2024