Neuron-specific enolase by IHC

Alphabetical Test listing

Neuron-specific enolase by IHC-12376 - Technical only, 12379 - Technical & Interpretation

Test name:

Test number:

12376 - Technical only, 12379 - Technical & Interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

NSE

Tests included:

All IHC stains will include a positive control tissue

Useful for:

May be useful in a panel for neuroendocrine tumors
Other more specific neuroendocrine markers include chromogranin, Synaptophysin, and Leu-7
Infrequent positive staining in many non-neuroendocrine tumors has been identified with NSE due to cross-reactivity

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin embedded tissue block

Transport container:

Formalin-fixed, paraffin embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled block
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

NSE is an isoenzyme of the glycolytic enzyme enolase that is expressed primarily in neurons and neuroendocrine tissues
NSE is also expressed in platelets, T-lymphocytes, megakaryocytes, striated and smooth muscle cells

Staining pattern

Diffuse cytoplasmic

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

07/18/2017

Revised date:

10/19/2018

Review date:

01/12/2024