Androgen receptor image by IHC

Alphabetical Test listing

Androgen receptor image by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test name:

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Alternate names:

Tests included:

All IHC stains will include a positive control tissue

Useful for:

Androgen receptor (AR) positivity may be used to identify patients with metastatic breast cancer who may benefit from Bicalutamide therapy (prostate cancer drug)
The majority of estrogen receptor positive breast cancers will also be AR positive; androgen receptors are most frequently seen in luminal A and B invasive breast cancers
ARs are also seen in approximately one-third of basal-like cancers
AR positive, estrogen receptor negative tumors are frequently apocrine type; these may be triple negative or HER2 positive tumors
Request AR IHC evaluation on breast cases using image analysis
AR is also useful in the diagnosis of salivary duct carcinomas. Approximately 90% of these tumors will be AR positive, and P63 negative

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin embedded tissue block

Transport container:

Formalin-fixed, paraffin embedded (FFPE) tissue block

Alternate transport container:

Tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Unlabeled/mislabeled
Insufficient tissue
Slides broken beyond repair

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications

This antibody is used to identify the androgen receptor in tumor cells

Staining patterns

Strong nuclear staining

References

Niemeier LA, Dabbs DJ et al: Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol (2010) 23, 205–212.
Collins LC et al: Androgen Receptor Expression in Breast Cancer in Relation to Molecular Phenotype: Results from the Nurses’ Health Study. Mod Pathol. 2011 July; 24(7): 924–931. doi:10.1038/modpathol.2011.54
Robinson JLL et al: Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. The EMBO Journal (2011) 30, 3019–3027.

CPT codes:

88342 - 1st stain
88341 - each additional stain
88361 - CAS Morphometric

Date created:

05/01/2017

Revised date:

02/25/2019

Review date:

01/12/2024