Myeloid NGS

Alphabetical Test listing

Myeloid NGS-14519

  
Myeloid NGS
  
14519
  
1230151400
  
Myeloid neoplasms
Myeloproliferative neoplasms
Myelodysplastic syndromes
MPN
MDS
Myeloid leukemias
AML
NGS
FLT3
IDH1
IDH2
TP53
NPM1
CEBPA
RUNX1
KIT
DNMT3A
KRAS
ASXL1
BCR/ABL
JAK2
CALR
MPL
MYD88
SF3B1
  

One of the customized panels can be selected below including any single gene add ons in the following tables.

  

This Myeloid NGS panel includes 71 genes. The panel consists a DNA component designed to detect mutations as well as an RNA component designed to detect gene fusions. This test is intended for the molecular evaluation of myeloid neoplasms, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), myelodysplastic/myeloproliferative neoplasms, and myeloid leukemias (AML) among others.  The detection of molecular alterations described in these neoplasms can be useful in their diagnosis and classification. In addition, the pattern of particular alterations can be prognostically informative and can have implications for the use of both targeted and conventional therapies. This NGS panel will serve to consolidate several single gene assays into a single test.  Preset gene panels are available for order as well as individual genes if desired. 

  
EDTA whole blood
  
  
3.0 mL
  
1.0 mL
  

Immediately following collection, mix sample by inverting 8 - 10 times to prevent clotting.

  

Submit unspun

  
ACD whole blood
Sodium citrate (Na cit) whole blood
Bone marrow in EDTA
  

 Yellow ACD (A or B)

 

Lt blue Sodium citrate (Na Cit) - 2.7mL 

Bone marrow - collected in EDTA 

  
3.0 mL
  

 Yellow ACD (A or B)

 

Lt blue Sodium citrate (Na Cit) - 2.7mL 

Bone marrow - collected in EDTA 

  

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

  

Refrigerated (preferred) - 7 days

Ambient - 4 days

Do not freeze

  
14 days
  
  • Heparin collection
  • Frozen specimens
  
AHL - Molecular Diagnostics: D
  
Varies
  
6 - 14 days
  

Next Generation Sequencing

  

One of the customized panels can be selected below including any single gene add ons in the following tables.

Customized panel Genes included
AML Therapeutic FLT3, IDH1, IDH2, TP53
AML/MDS/Myeloid - Limited Panel TP53, FLT3, NPM1, CEBPA, IDH1, IDH2, RUNX1, KIT, DNMT3A, KRAS, NRAS, ASXL1
Myeloproliferative Neoplasm NOS BCR/ABL, JAK2, CALR, MPL
Myeloproliferative Neoplasm, not CML JAK2, CALR, MPL
Myeloproliferative Neoplasm, suspicious for PV JAK2
Myeloid full DNA and RNA panels See below
Myeloid full DNA panel only See below
Custom Panel Choose specific genes below

 

*Individual genes can be selected in addtion to the panels listed above

DNA Panel: Hotspot Genes









DNA Panel: Full Genes













RNA Panel: fusion driver genes
ANKRD26 KRAS ASXL1 PRPF8 ABL1 KAT6A (MOZ) NUP214
ABL1 MPL BCOR RB1 ABL2 KAT6B PAX5
BRAF MYD88 CALR RUNX1 BCL2 KMT2A PDGFRA
CBL NPM1 CEBPA SH2B3 BRAF KMT2A PTDs PDGFRB
CSF3R NRAS ETV6 STAG2 CCND1 MECOM RARA
DDX41 PPM1D EZH2 TET2 CREBBP MET RUNX1
DNMT3A PTPN11 IKZF1 TP53 EGFR MLLT10 TCF3
FLT3 (ITD, TKD) SMC1A NF1 ZRSR2 ETV6 MRTFA(MKL1) TFE3
GATA2 SMC3 PHF6   FGFR1 MYBL1 ZNF384
HRAS SETBP1     FGFR2 MYH11  
IDH1 SF3B1     FUS NTRK2  
IDH2 SRSF2     HMGA2 NTRK3  
JAK2 U2AF1     JAK2 NUP98  
KIT WT1          
  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
AML Therapeutic: 81245, 81246, 81120, 81121, 81352
AML/MDS/Myeloid - Limited Panel: 81450
Myeloproliferative Neoplasm NOS: 81450
Myeloproliferative Neoplasm, not CML: 81279, 81219, 81338
Myeloproliferative Neoplasm, suspicious for PV: 81279
DNA Panel: Hotspot Genes: 81450
DNA Panel: Full Genes: 81450
RNA Panel: fusion driver genes: 81450
MYELOID NGS JAK2 EXON 12-15: 81279
MYELOID NGS CALR: 81219
MYELOID NGS MPL: 81338
MYELOID NGS IDH1: 81120
MYELOID NGS IDH2: 81121
MYELOID NGS SF3B1:81347
MYELOID NGS MYD88: 81305
MYELOID NGS BRAF: 81210
MYELOID NGS KIT: 81272
MYELOID NGS TP53: 81352
MYELOID NGS FLT3 ITD: 81245
MYELOID NGS FLT3 TKD: 81246
MYELOID NGS JAK2 V617F: 81270
MYELOID NGS NPM1: 81310
MYELOID NGS CEBPA: 81218
MYELOID NGS RARA: 81315
MYELOID NGS BCR/ABL: 81206
MYELOID NGS KRAS CODONS 12 AND 13: 81275
MYELOID NGS KRAS CODONS 61 AND 146: 81276
MYELOID NGS NRAS: 81311

Codes listed are associated with most common orders and is not inclusive of all potential orders
  
Yes
  

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare billing request

  
11/21/2023
  
05/15/2024
  
01/15/2024