Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

Tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Glypicans are heparan sulfate proteoglycans (HSPGs) that are linked to the cell membrane by a glycosyl phosphatidylinositol (GPI) anchor
• GPC3 is upregulated at mRNA and protein level in hepatocellular CA
• Appears to be oncofetal (in fetal but not adult normal livers)

Staining pattern

• Granular cytoplasmic and membranous staining