Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum

Alphabetical Test listing

Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

AIAES
Autoimmune Neuropathy
Peripheral Neuropathy
Neuropathy
Axonal Neuropathy
Polyradiculopathy
Autonomic Neuropathy
Motor Neuropathy
Sensory Neuropathy
Small Fiber Neuropathy

Useful for:

Evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
Directing a focused search for cancer
Investigating neurological symptoms that appear during, or after, cancer therapy and are not explainable by metastasis
Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
Detecting early evidence of cancer recurrence in previously seropositive patients

Patient preparation information:

For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin (IVIg) treatment.

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube x 2

Volume:

4 mL

Minimum volume:

2 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gentle inversion, 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within two (2) hours of sample collection
Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum

Transport container:

Screw cap transfer vial/tube (Mayo T914)

Alternate collection container:

Red serum vial/tube, 5 mL x 2

Red serum vial/tube, 10 mL

Transport and stability:

Refrigerated (preferred) – 28 days

Frozen – 28 days

Ambient – 72 hours

Reason for rejection:

Gross hemolysis
Gross lipemia
Gross icterus

Performing lab:

Mayo Clinic Laboratories (AIAES): R-NX

Days set up:

Mo - Su
Reflex tests: Varies

TAT:

8 - 12 days

Method:

Cell-Binding Assay
Indirect Immunofluorescence Assay
Western Blot
Immunoblot

Reference ranges:

See report

Clinical information:

Utilization guidelines for neurologic autoimmune panels

Autoimmune/Paraneoplastic Movement Disorder Evaluation Algorithm-Serum

CPT codes:

86255 x 12
84182 Additional CPT codes (if appropriate): 84182 AGNBS
86256 AGNTS
86255 AINCS
84182 AMIBS
84182 AN1BS
86256 AN1TS
84182 AN2BS
86256 AN3TS
86255 APBCS
86256 APBTS
86256 APHTS
86256 CRMTS
86255 GFACS
86256 GFATS
86256 IG5TS
86255 NFHCS
86255 NFLCS
86256 NIFTS
84182 PC1BS
86256 PC1TS
86256 PC2TS

Date created:

08/05/2025

Review date:

08/05/2025