Amyloid protein identification, paraffin, LC-MS-MS

Alphabetical Test listing

Test name:

Test number:

Pathology add-on

Alternate names:

Amyloid AA
Amyloid AL
Amyloid ATTR
Amyloid LECT-2
Amyloid
GPAMYPROPAR
GPMSCBB

Tests included:

In all cases with adequate tissue, an initial Congo red stain is performed before mass spectrometry testing to confirm positivity and pattern of amyloid deposition can be considered when interpreting mass spectrometry results.
In some instances, per pathologist discretion, a different initial Congo red stain may be performed using SS2PC / Special Stain, Group II, Other

Limitations:

This test should only be ordered on patients in whom a primary diagnosis has already been established

Specimen type:

Tissue

Processing instructions:

Testing can only be performed on FFPEtissue blocks.; Do not send fixed tissue slides

Transport container:

Formalin-fixed paraffin-embedded (FFPE) tissue block

Alternate transport container:

B5-fixed paraffin-embedded (FFPE) tissue block

Required forms/information:

Transport and stability:

Ambient (preferred)

Refrigerated (OK)

Reason for rejection:

Performing lab:

Mayo Clinic Laboratories (AMPIP): R-NX

Days set up:

Mo - Fr

TAT:

7 - 15 days

Method:

Histological stain Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Reference ranges:

An interpretative report will be provided

CPT codes:

88313
82542 (if appropriate)
88380 (if appropriate)

Date created:

05/21/2018

Revised date:

11/14/2018

Review date:

03/08/2023